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Cat. No. | Product Name | Target | Signaling Pathways |
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T6503 |
Fluorometholone Acetate
NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate |
Glucocorticoid Receptor; Carbonic Anhydrase | Endocrinology/Hormones; Metabolism |
Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性,可用于研究外部眼部炎症。 | |||
T0515 |
Tioxolone
|
Carbonic Anhydrase | Metabolism |
Tioxolone 是一种金属酶碳酸酐酶 I 抑制剂,具有抗痤疮作用。 | |||
T63305 |
Carbonic anhydrase inhibitor 6
|
Carbonic Anhydrase | Metabolism |
Carbonic anhydrase inhibitor 6 是一种高效的人碳酸酐酶 (hCA) 抑制剂,抑制 hCA IX,hCA II,hCA XII和hCA I,可用于研究碳酸酐酶异常引起的疾病。 | |||
T36758 |
CAIX Inhibitor S4
S4 |
Carbonic Anhydrase | Metabolism |
CAIX Inhibitor S4 (S4) 是一种有效的碳酸酐酶 IX/XII 抑制剂,Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。 | |||
T2134 |
Dorzolamide hydrochloride
MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl |
Carbonic Anhydrase | Metabolism |
Dorzolamide hydrochloride (MK507 hydrochloride) 是一种碳酸酐酶carbonic anhydrase II 抑制剂,能够抑制红细胞CA-II(IC50:0.18 nM) 和CA-I(IC50:600 nM) 。 | |||
T23782 |
Benzolamide
CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803 |
Carbonic Anhydrase | Metabolism |
Benzolamide (CL 11366) 是碳酸酐酶 (CA) 抑制剂,抑制hCA I(Ki:15 nM)、hCA II(Ki:9 nM)、EcoCAγ(Ki:94 nM)、VchCAγ(Ki:78 nM)、CAS3(Ki:54 nM)。它可用于研究青光眼和癫痫。 | |||
T61745 |
hCAI/II-IN-6
|
Carbonic Anhydrase | Metabolism |
hCAI/II-IN-6 是一种具有选择性和口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6对 hCA I,hCA II,hCA VII 和 hCA XII 有抑制作用,Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性。hCAI/II-IN-6 可以用于研究癫痫。 | |||
T0782 |
Benzthiazide
Aquatag,苄噻嗪,Lemazide,Dihydrex |
Carbonic Anhydrase | Metabolism |
Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂,他对 CA9,CA2 和 CA1 的 Ki 分别为 8.0,8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。 | |||
T61980 | Carbonic anhydrase inhibitor 8 | ||
Carbonic anhydrase inhibitor 8 (compound R-13) 是一种有效的人碳酸酐酶 (hCA) 抑制剂。Carbonic anhydrase inhibitor 8抑制 hCA I、hCA II、hCA IV 的Ki 值分别为 60.7 nM、320.7 nM、2298 nM。 | |||
T61982 | Human carbonic anhydrase II-IN-2 | ||
Human carbonic anhydrase II-IN-24 (Compound R-13) 是一种有效的人碳酸酐酶(hCA)抑制剂。Human carbonic anhydrase II-IN-24抑制 hCA I、II、IV 和 IX 的 Ki 分别为 60.7、320.7 和 2298 和 35.2 nM。 | |||
T61829 | Carbonic anhydrase inhibitor 4 | ||
Carbonic anhydrase inhibitor 4 is a photoprobe that inhibits the activity of carbonic anhydrase. It specifically targets human carbonic anhydrases, including hCA I-XIV, with K i values ranging from 640-1166 nM [1]. | |||
T62666 |
Carbonic anhydrase inhibitor 7
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Carbonic anhydrase inhibitor 7 是一种人碳酸酐酶 (hCA) 的有效抑制剂,作用于 hCA IX (Ki: 6.5 nM),hCA II (Ki: 7.1 nM),hCA XII (Ki: 72.1 nM) 和 hCA I (Ki: 255.8 nM)。 | |||
T61842 | Carbonic anhydrase inhibitor 14 | ||
Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibits CDK2 with an IC 50 of 20.3 μM. Furthermore, Carbonic anhydrase inhibitor 14 demonstrates significant antitumor activity [1]. | |||
T61981 | Human carbonic anhydrase II-IN-1 | ||
Human carbonic anhydrase II-IN-1 (Compound S-13) 是一种有效的人碳酸酐酶 II (hCA II) 抑制剂。Human carbonic anhydrase II-IN-1抑制 hCA II,其他 hCA 同工型 I、IV 和 IX 的分别 Ki 为 4.4 nM、 9.2 nM、480.2 nM 和 14.7 nM。Human carbonic anhydrase II-IN-1可用于青光眼的研究。 | |||
T62026 |
hCAIX-IN-11
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hCAIX-IN-11 (Compound 5d) 是选择性的碳酸酐酶 (carbonic anhydrase) IX 和 XII 抑制剂。hCAIX-IN-11抑制 hCA IX 和 hCA XII 的Ki 分别为 32.7 和 623.5 nM。 | |||
T63557 |
hCA I-IN-1
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hCA I-IN-1 是一种人碳酸酐酶 I (hCA I)抑制剂,能够作用于 hCA I (Ki: 38.3 nM)、hCA II (Ki: 716.4 nM)、hCAIX (Ki: 940.1 nM) 和 hCAXII (Ki: 192.8 nM)。 | |||
T63972 |
hCA I-IN-2
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hCA I-IN-2 (Compound 6d) 是人碳酸酐酶 I (hCA I)的选择性抑制剂,能够作用于 hCA I (Ki: 18.8 nM)、hCA II (Ki: 375.1 nM)、hCAIX (Ki: 1721 nM) 和 hCAXII (Ki: 283.9 nM)。 | |||
T62892 |
hCAI/II-IN-1
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hCAI/II-IN-1 (Compound 3h) 是一种人碳酸酐酶 I 和 II (hCA I/II) 抑制剂,作用于 hCA I (IC50: 0.047 μM) 和 hCA II (IC50: 0.024 μM)。 | |||
T62101 |
hCAXII-IN-2
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hCAXII-IN-2 (compound 5i) 是一种人碳酸酐酶 XII (hCA XII) (Ki: 84.2 nM) 和 hCA IX (Ki: 268.5 nM) 的有效抑制剂,对 hCA I 和 hCA II 具有较低的活性。 | |||
T61164 | hCAII-IN-3 | ||
hCAII-IN-3 (Compound 16) is an inhibitor of human carbonic anhydrase (hCA). It exhibits high affinity for hCA I, hCA II, hCA IX, and hCA XII, with Ki values of 403.8 nM, 5.1 nM, 10.2 nM, and 5.2 nM, respectively. Notably, hCA IX-IN-2 demonstrates anticancer activity [1]. | |||
T61282 |
hCAI/II-IN-2
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hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its anti-hypoxic properties, hCAI/II-IN-2 demonstrates activity against acute mountain sickness (AMS). Furthermore, this compound exhibits low cellular activity [1]. | |||
T74331 | hCAII-IN-7 | ||
hCAII-IN-7 (Compound R-13) 是一种有效的人碳酸酐酶(hCA)抑制剂,对 hCA I、II、IV 和 IX 的 Ki 分别为 60.7、320.7 和 2298 和 35.2 nM。 | |||
T72840 |
hCAIX/XII-IN-6
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hCAIX/XII-IN-6 是具有口服活性的碳酸酐酶(CA)抑制剂,能够抑制人体 CA 亚型 hCA I、II、IV、IX 及 XII,其 Ki 值分别为 6697 nM、2950 nM、4093 nM、4.1 nM 和 7.7 nM。适用于类风湿关节炎(RA)研究。 | |||
T63631 |
hCAII-IN-2
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hCAII-IN-2 是胞质型人碳酸酐酶 (hCA) 抑制剂,能够作用于 hCA I (Ki: 261.4 nM)、hCA II (Ki: 3.8 nM)、hCA IX (Ki: 19.6 nM)和 hCA XII (Ki: 45.2 nM)。 | |||
T61263 | hCA IX-IN-1 | ||
hCA IX-IN-1 (Compound 6f) 是一种人碳酸酐酶 (hCA) 抑制剂,对 hCA I、hCA II、hCA IX 和 hCA XII 的 Ki 值分别为 331.4、28.4、9.4 和 17.8 nM。 | |||
T72122 |
Carbonic anhydrase inhibitor 12
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Carbonic Anhydrase | Metabolism |
碳酸酐酶抑制剂12是针对CA II具有高效抑制作用的化合物,其Kis值仅为1.72 nM,对CA I亦表现出有效抑制(Kis为271 nM)。此外,该化合物在多种肿瘤细胞系中显示出显著的抗癌活性。 | |||
T74486 | hCAIX-IN-17 | ||
hCA IX-IN-1 (Compound 6f) 是一种人碳酸酐酶 (hCA) 抑制剂,对hCA I、hCA II、hCA IX 和hCA XII 的Ki 值分别为 331.4、28.4、9.4 和 17.8 nM。 | |||
T74330 | hCAII-IN-6 | ||
hCAII-IN-6 (Compound S-13) 是一种有效的人碳酸酐酶 II (hCA II) 抑制剂,Ki 为 4.4 nM。hCAII-IN-6 还抑制其他 hCA 同工型 I、IV 和 IX,Ki 值分别为 9.2 nM、480.2 nM 和 14.7 nM, 并可用于青光眼的研究。 | |||
T60602 | hCAIX/XII-IN-5 | ||
hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂,具有出色的 hCA IX/XII 选择性,对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性,可延迟细胞周期并诱导细胞凋亡。 | |||
T79748 |
hCAIX/XII-IN-7
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Carbonic Anhydrase | Metabolism |
hCAIX/XII-IN-7(compound 3e)为高效的hCA IX与XII抑制剂,对hCA I、II、IX与XII的Ki值分别为3.2 nM、9.2 nM、503.7 nM及59 nM,显示其在缺氧肿瘤研究中的应用潜力。 | |||
T64102 | hCAI/II-IN-5 | ||
hCAI/II-IN-5 是 hCA I 和 hCA II (人碳酸酐酶同工酶 I 和 II) 的有效抑制剂,他们的IC50值分别为 37.88 和 45.23 nM。 hCAI/II-IN-5 也能够抑制 α-Glycosidase (IC50: 48.98 nM) 和 AChE (IC50: 420.14 nM)。hCAI/II-IN-5 能够用于研究糖尿病、心力衰竭、阿尔茨海默病、溃疡、癫痫等多种疾病。 | |||
T63764 | hCA XII/II/IX-IN-1 | ||
hCA XII/II/IX-IN-1 是人碳酸酐酶 (hCA) 的有效抑制剂,能够作用于 hCA I (IC50: 2.6 μM)、 hCA II (IC50: 0.004 μM)、hCA IX (IC50: 0.005 μM) 和 hCA XII (IC50: 0.001 μM)。hCA XII/II/IX-IN-1 表现出抗癌效果。 | |||
T35840 | 4-Amino-6-chloro-1,3-benzenedisulfonamide | ||
4-Amino-6-chloro-1,3-benzenedisulfonamide is a carbonic anhydrase inhibitor.1 Formulations containing this compound are diuretics.2 4-Amino-6-chloro-1,3-benzenedisulfonamide is detected as a hydrolysis product of chlorothiazide in the urine.2 Diuretics, including chlorothiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.3References1. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies ... | |||
T74978 | DPP IV/hCA II-IN-1 | ||
DPP IV/hCA II-IN-1 是一种有效的选择性二肽肽酶 IV (DPP IV) 和碳酸酐酶 (CA) 抑制剂,抑制 DPP IV 的 IC50值为 0.049 μM, 抑制 CA II、CA VB、CA VA、CA IX、CA I 和 CA IV 的 Ki 值分别为 0.0361、0.0428、0.0941、0.1328、0.2615 和 3.034 μM。 | |||
T78729 |
hCAIX/VII-IN-1
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Carbonic Anhydrase | Metabolism |
hCAIX/VII-IN-1是一种选择性hCA VII/IX抑制剂,对hCAⅠ、hCAⅡ、hCAⅣ、hCAⅦ和hCAⅨ的Ki值分别为336.2 nM、185.8 nM、1055 nM、35.6 nM和28.0 nM。hCAIX/VII-IN-1主要用于癌症和神经疾病的研究。 | |||
T63941 |
α-Glycosidase-IN-1
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α-Glycosidase-IN-1 (compound MZ7) 是 α-GLY(α- 糖苷酶) 的有效抑制剂 (IC50: 44.72 nM, Ki: 44.74 nM)。α-Glycosidase-IN-1 也能够抑制人碳酸酐酶同工酶 I 和 II (hCA I 和hCA II)以及乙酰胆碱酯酶 (AChE),其IC50值分别为 104.87、100.04 和 654.87 nM。α-Glycosidase-IN-1 能够用于研究糖尿病、阿尔茨海默病、溃疡、心力衰竭、癫痫等多种疾病。 | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
T63400 |
hA2A/hCA XII modulator 1
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hA2A/hCA XII modulator 1 是 hA2A 腺苷受体 (hA2AAR) 的有效拮抗剂,是一种三唑并吡嗪, 能够作用于hA2AAR (Ki: 6.4 nM)、hA1AR (Ki: 4.819 μM)、hA3AR (Ki>30 μM)。hA2A/hCA XII modulator 1 也人碳酸酐酶 XII (hCA XII) 的有效抑制剂,能够作用于 hCA XII (Ki: 6.2 nM)、hCA II (Ki: 46 nM)、hCA IX (Ki: 466 nM) 和 hCA I (Ki: 8.351 μM)。hA2A/hCA XII modulator 1 表现出研究癌症的潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN2095 |
Pomiferin
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NOS; NF-κB; PDE | Immunology/Inflammation; Metabolism; NF-κB |
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities. |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00731 |
Carbonic Anhydrase 1 Protein, Human, Recombinant (His)
Carbonic Anhydrase B,Carbonate De... |
Human | E. coli |
Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonam... | |||
TMPH-03258 |
Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO)
Cyanamide hydratase CA1,CA-I,Carbonate deh... |
Rat | E. coli |
Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the accession number is B0BNN3. |